News:

  • 2025/07/07:

    Great and fruitful collaboration with the Haitin group, this time on GGPPS (aka "another prenyl transferase"). Inspiring work on enzyme oligomerization using HDX and native MS. And a second PhD paper for Jasmin! 🎉

  • 2025/06/25:

    Congrats to Pepa 🎉 👏 on a successful PhD defense. Good luck in your furture steps Pepa and thanks for all the fun!

  • 2025/06/25:

    We are organizing a hands-on Structural MS workshop supported by the OP JAK – Photomachines project and the SPIDoc's doctoral network. This is a unique opportunity to learn sample preparation, analysis, and data processing in HDX-MS, native MS, top-down MS, and cross-linking MS - topped off with a touch of ultra-high-resolution mass spectrometry! Don’t miss your chance to register. The workshop will take place on September 15–19, 2025, at BIOCEV.

  • 2025/06/05:

    Great news! 🎉 👏 Ljubi has successfully defended her PhD thesis. Well done, Doctor!

  • 2025/05/29:

    Congratulations to Kuba on successfully defending his master’s thesis! The gate to a PhD is now open!

  • 2025/05/11:

    Well, it took some time, but we’ve finally brought HDX analysis of the Cl⁻/H⁺ antiporter to a high-resolution, high-throughput level, allowing analysis of numerous conditions and pH-matching time points — and the timing couldn’t have been better. Our findings align beautifully with cryo-EM structures from groups at Stanford and offer key insights into the mechanism of chloride/proton transport. The preprint is now live on BioRxiv. Great work, Jasmin and Luky!

  • 2025/05/11:

    That was the first time we started doing fast HDX at low temperature and were locked with Paja in a cold room - cis-PT times. Now the story goes out through a collaborative effort of three groups, led by the Haitin group! Nature *Whatever*, here we come!

  • 2025/04/30:

    Alan's work on coupling a q-TOF mass spectrometer to a synchrotron is now out in Phys. Chem. Chem. Phys.. Check out how protein ions can be dissociated using tools not typically accessible in mass spectrometry.

  • 2025/04/25:

    Get ready to take the next step in your career journey! Join us for the SPIDoc's Career Day, connect with professionals and discover diverse career pathways. When: May 16, 2025. Where: Biocev, CZ or online. See more details in the flyer.

  • 2025/04/16:

    A new paper, led by our current and former students (Valča, Rosi and Michael) shows how combining novel isotopically labeled, MS-cleavable cross-linkers with DIA-MS acquisition improves the description of structural changes in therapeutic proteins.

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Important:

Collaboration

Academic:

Yoni Haitin and Moshe Giladi - Tel Aviv University, Israel

Daniel Khananshvili,Tel Aviv University, Israel

Charlotte Uetrecht, Centre for Structural Systems Biology, Hamburg, Germany

Petr Beier, Institute of Organic Chemistry and Biochemistry, Prague, Czech Republic

Angel L. Pey, University of Granada, Spain

Daniele Fabris, University of Connecticut, Storrs, Connecticut, U.S.A.

Alice Sosic, University of Padova, Italy

Athi N. Naganathan, Indian Institute of Technology Madras, India

Industry:

Bruker Daltonics

SOTIO

Nested Therapeutics

CF Plus Chemicals s.r.o.

The Antibody Lab