Laboratory of Structural Biology and Cell Signaling

News:

2025/07/07:
Great and fruitful collaboration with the Haitin group, this time on GGPPS (aka "another prenyl transferase"). Inspiring work on enzyme oligomerization using HDX and native MS. And a second PhD paper for Jasmin! 🎉
2025/06/25:
Congrats to Pepa 🎉 👏 on a successful PhD defense. Good luck in your furture steps Pepa and thanks for all the fun!
2025/06/25:
We are organizing a hands-on Structural MS workshop supported by the OP JAK – Photomachines project and the SPIDoc's doctoral network. This is a unique opportunity to learn sample preparation, analysis, and data processing in HDX-MS, native MS, top-down MS, and cross-linking MS - topped off with a touch of ultra-high-resolution mass spectrometry! Don’t miss your chance to register. The workshop will take place on September 15–19, 2025, at BIOCEV.
2025/06/05:
Great news! 🎉 👏 Ljubi has successfully defended her PhD thesis. Well done, Doctor!
2025/05/29:
Congratulations to Kuba on successfully defending his master’s thesis! The gate to a PhD is now open!
2025/05/11:
Well, it took some time, but we’ve finally brought HDX analysis of the Cl⁻/H⁺ antiporter to a high-resolution, high-throughput level, allowing analysis of numerous conditions and pH-matching time points — and the timing couldn’t have been better. Our findings align beautifully with cryo-EM structures from groups at Stanford and offer key insights into the mechanism of chloride/proton transport. The preprint is now live on BioRxiv. Great work, Jasmin and Luky!
2025/05/11:
That was the first time we started doing fast HDX at low temperature and were locked with Paja in a cold room - cis-PT times. Now the story goes out through a collaborative effort of three groups, led by the Haitin group! Nature *Whatever*, here we come!
2025/04/30:
Alan's work on coupling a q-TOF mass spectrometer to a synchrotron is now out in Phys. Chem. Chem. Phys.. Check out how protein ions can be dissociated using tools not typically accessible in mass spectrometry.
2025/04/25:
Get ready to take the next step in your career journey! Join us for the SPIDoc's Career Day, connect with professionals and discover diverse career pathways. When: May 16, 2025. Where: Biocev, CZ or online. See more details in the flyer.
2025/04/16:
A new paper, led by our current and former students (Valča, Rosi and Michael) shows how combining novel isotopically labeled, MS-cleavable cross-linkers with DIA-MS acquisition improves the description of structural changes in therapeutic proteins.

Important:

2025/06/25:
Register for the Structural MS hands-on workshop – September 15-19, 2025 at BIOCEV (CZ), and learn how to run and process HDX-MS, native MS, top-down MS, and cross-linking experiments. More details here.
2025/04/25:
Our DeutEx program was licensed to Bruker!
2024/04/05:
You can meet/follow us at BlueSky, X (Twitter) and we even have a YouTube channel!
2022/07/22:
Synopsis of Ales' Hippostruct MSCA project is available here.